Linked Life Data

18832728

Source:http://linkedlifedata.com/resource/pubmed/id/18832728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-10-3
pubmed:abstractText
Several lines of evidence suggest that the immune activation after myocardial infarction (MI) induces secondary myocardial injury. Although dendritic cells (DC) are potent regulators of immunity, their role in MI is still undetermined. We investigated the effect of DC modulation by CSF on left ventricular (LV) remodeling after MI. MI was induced by ligation of the left coronary artery in male Wistar rats. G-CSF (20 microg/kg/day, MI-G, n = 33), a GM-CSF inducer (romurtide, 200 microg/kg/day, MI-GM, n = 28), or saline (MI-C, n = 55) was administered for 7 days. On day 14, MI-G animals had higher LV max dP/dt and smaller LV dimensions, whereas MI-GM animals had lower LV max dP/dt and larger LV dimensions than did MI-C animals, despite similar infarct size. In MI-C, OX62(+) DC infiltrated the infarcted and border areas, peaking on day 7. Bromodeoxyuridine-positive DC were observed in the border area during convalescence. Infiltration by DC was decreased in MI-G animals and increased in MI-GM animals compared with MI-C (p < 0.05). In the infarcted area, the heat shock protein 70, TLR2 and TLR4, and IFN-gamma expression were reduced in MI-G, but increased in MI-GM in comparison with those in MI-C animals. IL-10 expression was higher in MI-G and lower in MI-GM than in MI-C animals. In conclusion, G-CSF improves and GM-CSF exacerbates early postinfarction LV remodeling in association with modulation of DC infiltration. Suppression of DC-mediated immunity could be a new strategy for the treatment of LV remodeling after MI.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5691-701
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18832728-Animals, pubmed-meshheading:18832728-Cell Movement, pubmed-meshheading:18832728-Dendritic Cells, pubmed-meshheading:18832728-Gene Expression Regulation, pubmed-meshheading:18832728-Granulocyte Colony-Stimulating Factor, pubmed-meshheading:18832728-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:18832728-HSP70 Heat-Shock Proteins, pubmed-meshheading:18832728-Humans, pubmed-meshheading:18832728-Interferon-gamma, pubmed-meshheading:18832728-Interleukin-10, pubmed-meshheading:18832728-Male, pubmed-meshheading:18832728-Myocardial Infarction, pubmed-meshheading:18832728-Rats, pubmed-meshheading:18832728-Rats, Wistar, pubmed-meshheading:18832728-Toll-Like Receptor 2, pubmed-meshheading:18832728-Toll-Like Receptor 4, pubmed-meshheading:18832728-Ventricular Remodeling
pubmed:year
2008
pubmed:articleTitle
Differential effects of GM-CSF and G-CSF on infiltration of dendritic cells during early left ventricular remodeling after myocardial infarction.
pubmed:affiliation
Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article