Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2008-10-2
pubmed:abstractText
NAD(P)H:quinone oxidoreductase 1 null (NQO1(-/-)) mice exposed to 3 Gy of gamma-radiation showed an increase in neutrophils, bone marrow hypercellularity, and enlarged lymph nodes and spleen. The spleen showed disrupted follicular structure, loss of red pulp, and granulocyte and megakarocyte invasion. Blood and histologic analysis did not show any sign of infection in mice. These results suggested that exposure of NQO1(-/-) mice to gamma-radiation led to myeloproliferative disease. Radiation-induced myeloproliferative disease was observed in 74% of NQO1(-/-) mice as compared with none in wild-type (WT) mice. NQO1(-/-) mice exposed to gamma-radiation also showed lymphoma tissues (32%) and lung adenocarcinoma (84%). In contrast, only 11% WT mice showed lymphoma and none showed lung adenocarcinoma. Exposure of NQO1(-/-) mice to gamma-radiation resulted in reduced apoptosis in granulocytes and lack of induction of p53, p21, and Bax. NQO1(-/-) mice also showed increased expression of myeloid differentiation factors CCAAT/enhancer binding protein alpha (C/EBPalpha) and Pu.1. Intriguingly, exposure of NQO1(-/-) mice to gamma-radiation failed to induce C/EBPalpha and Pu.1, as was observed in WT mice. These results suggest that decreased p53/apoptosis and increased Pu.1 and C/EBPalpha led to myeloid hyperplasia in NQO1(-/-) mice. The lack of induction of apoptosis and differentiation contributed to radiation-induced myeloproliferative disease in NQO1(-/-) mice.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-10208650, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-10397748, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-10463613, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-10471077, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11085502, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11087871, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11160862, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11222389, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11309386, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11417483, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-11481389, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12036909, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12063023, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12070033, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12232053, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12393620, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12592334, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-12615705, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-15110384, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-15146183, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-15342368, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-1575764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-15781611, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-16113082, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-16550160, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-16846973, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-1737339, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-17420284, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-17443228, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-17545619, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-17629523, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-3652818, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-59808, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-8528266, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-9012825, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-9230185, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-9328142, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-9516435, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-9573007, http://linkedlifedata.com/resource/pubmed/commentcorrection/18829548-9825838
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1538-7445
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7915-22
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease.
pubmed:affiliation
Department of Pharmacology, Baylor College of Medicine, Houston, Texas, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural