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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-2-24
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pubmed:abstractText |
An elevated number of Gr-1(+)CD11b(+) myeloid-derived suppression cells (MDSCs) has been described in mice and human bearing tumor and associated with immune suppression. Arginase I production by MDSCs in the tumor environment may be a central mechanism for immunosuppression and tumor evasion. In this study and before, we found that Gr-1(+)CD11b(+) MDSCs from ascites and spleen of mice bearing ovarian 18D carcinoma express a high level of PD-1, CTLA-4, B7-H1 and CD80 while other co-stimulatory molecules, namely CD40, B7-DC and CD86 are not detected. Further studies showed that PD-1 and CTLA-4 on the Gr-1(+)CD11b(+) MDSCs regulated the activity and expression of arginase I. The blockage and silencing of PD-1, CTLA-4 or both PD-1 and CTLA4 molecules could significantly reduce arginase I activity and expression induced with tumor-associated factor. Similar results were also observed while their ligands B7-H1 and/or CD80 were blocked or silenced. Furthermore, CD80 deficiency also decreased the arginase I expression and activity. Antibody blockade or silencing of PD-1, CTLA-4 or both reduced the suppressive potential of PD-1+CTLA-4+MDSCs. Blockade of PD-1, CTLA-4 or both also slowed tumor growth and improved the survival rate of tumor-bearing mice. Thus, there may exist a coinhibitory and costimulatory molecules-based immuno-regulating net among MDSCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11b,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Arginase,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gr-1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1432-0851
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
687-97
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18828017-Animals,
pubmed-meshheading:18828017-Antibodies, Monoclonal,
pubmed-meshheading:18828017-Antigens, CD,
pubmed-meshheading:18828017-Antigens, CD11b,
pubmed-meshheading:18828017-Antigens, CD274,
pubmed-meshheading:18828017-Antigens, CD80,
pubmed-meshheading:18828017-Antigens, Surface,
pubmed-meshheading:18828017-Apoptosis Regulatory Proteins,
pubmed-meshheading:18828017-Arginase,
pubmed-meshheading:18828017-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18828017-CTLA-4 Antigen,
pubmed-meshheading:18828017-Carcinoma,
pubmed-meshheading:18828017-Cell Line, Tumor,
pubmed-meshheading:18828017-Enzyme Induction,
pubmed-meshheading:18828017-Female,
pubmed-meshheading:18828017-Male,
pubmed-meshheading:18828017-Membrane Glycoproteins,
pubmed-meshheading:18828017-Mice,
pubmed-meshheading:18828017-Mice, Inbred C57BL,
pubmed-meshheading:18828017-Neoplasm Proteins,
pubmed-meshheading:18828017-Ovarian Neoplasms,
pubmed-meshheading:18828017-Peptides,
pubmed-meshheading:18828017-Programmed Cell Death 1 Receptor,
pubmed-meshheading:18828017-RNA, Small Interfering,
pubmed-meshheading:18828017-RNA Interference,
pubmed-meshheading:18828017-Receptors, Chemokine,
pubmed-meshheading:18828017-Specific Pathogen-Free Organisms
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pubmed:year |
2009
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pubmed:articleTitle |
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells.
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pubmed:affiliation |
Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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