|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005684,
umls-concept:C0021760,
umls-concept:C0037083,
umls-concept:C0044602,
umls-concept:C0285761,
umls-concept:C0334227,
umls-concept:C0441472,
umls-concept:C0752312,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1150481,
umls-concept:C1368105,
umls-concept:C1370600,
umls-concept:C1451005,
umls-concept:C1704632,
umls-concept:C1705325,
umls-concept:C1706817,
umls-concept:C1710082,
umls-concept:C2911692
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2009-2-2
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|
pubmed:abstractText |
Toll-like receptor 4 (TLR4) was found to be aberrantly expressed in bladder cancer, inducing some genes expression and facilitating tumor progression. Recent data suggest that tumor associated Interleukin-6 (IL-6) correlates with tumor size and grade in bladder cancer. However, the molecule mechanisms of the induction of IL-6 response in bladder cancer cells are not well elucidated. In this study, we manage to find out whether TLR4 signaling is involved in the production of IL-6 by human bladder cancer cells, and the detailed molecule mechanisms by which IL-6 is up-regulated.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1432-1335
|
|
pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
135
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
379-86
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18825409-Antigens, CD14,
pubmed-meshheading:18825409-Cell Line, Tumor,
pubmed-meshheading:18825409-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18825409-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18825409-Humans,
pubmed-meshheading:18825409-Interleukin-6,
pubmed-meshheading:18825409-Lipopolysaccharides,
pubmed-meshheading:18825409-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18825409-Toll-Like Receptor 4,
pubmed-meshheading:18825409-Urinary Bladder Neoplasms,
pubmed-meshheading:18825409-p38 Mitogen-Activated Protein Kinases
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling.
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|
pubmed:affiliation |
Department of Hepatobiliary Pancreatic Surgery, Key Lab of Organ Transplantation of Zhejiang Province, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
