| pubmed-article:18820938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C1553355 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C0042900 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:18820938 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:18820938 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18820938 | pubmed:dateCreated | 2008-12-24 | lld:pubmed |
| pubmed-article:18820938 | pubmed:abstractText | Vitiligo is a common skin disorder that is caused by selective destruction of melanocytes, resulting in disfiguring loss of pigment. There are convincing evidences that cytokines and T cell mediated immunity may have a role in its pathogenesis. Given the fact that cytokine production is under genetic control, in this study, we have investigated IFN-gamma +874 T/A and TNF-alpha -308 G/A gene polymorphisms in a total of 176 vitiligo patients and 545 controls. IFN-gamma +874 T/A and TNF-alpha -308 G/A gene polymorphisms were genotyped via Allele Specific Oligonucleotide PCR (ASO-PCR) method. The results showed that the TNF-alpha -308 G/A polymorphism was more common in vitiligo patients than controls (P = 0.0004). This difference was only significant between female patients and controls (P < 0.0001), while there was no significant difference between male patients and male controls (P = 0.90). The distribution of IFN-gamma genotypes in vitiligo patients did not differ significantly from that in control subjects (P = 0.56). Since the presence of A nucleotide at position -308 of TNF-alpha gene is associated with increased cytokine production, therefore, the higher frequency of TNF-alpha -308 A allele in vitiligo patients compared to controls may be considered as a genetic susceptibility factor towards the development of vitiligo. | lld:pubmed |
| pubmed-article:18820938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18820938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18820938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18820938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18820938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18820938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18820938 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18820938 | pubmed:issn | 1432-069X | lld:pubmed |
| pubmed-article:18820938 | pubmed:author | pubmed-author:Kamali-Sarves... | lld:pubmed |
| pubmed-article:18820938 | pubmed:author | pubmed-author:NamianAli-Moh... | lld:pubmed |
| pubmed-article:18820938 | pubmed:author | pubmed-author:ShahbazShimaS | lld:pubmed |
| pubmed-article:18820938 | pubmed:author | pubmed-author:SalmanpoorRah... | lld:pubmed |
| pubmed-article:18820938 | pubmed:author | pubmed-author:NamaziMohamma... | lld:pubmed |
| pubmed-article:18820938 | pubmed:author | pubmed-author:DehghaniFarid... | lld:pubmed |
| pubmed-article:18820938 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18820938 | pubmed:volume | 301 | lld:pubmed |
| pubmed-article:18820938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18820938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18820938 | pubmed:pagination | 21-5 | lld:pubmed |
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| pubmed-article:18820938 | pubmed:meshHeading | pubmed-meshheading:18820938... | lld:pubmed |
| pubmed-article:18820938 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18820938 | pubmed:articleTitle | Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients. | lld:pubmed |
| pubmed-article:18820938 | pubmed:affiliation | Department of Dermatology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. | lld:pubmed |
| pubmed-article:18820938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18820938 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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