Source:http://linkedlifedata.com/resource/pubmed/id/18820938
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-12-24
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| pubmed:abstractText |
Vitiligo is a common skin disorder that is caused by selective destruction of melanocytes, resulting in disfiguring loss of pigment. There are convincing evidences that cytokines and T cell mediated immunity may have a role in its pathogenesis. Given the fact that cytokine production is under genetic control, in this study, we have investigated IFN-gamma +874 T/A and TNF-alpha -308 G/A gene polymorphisms in a total of 176 vitiligo patients and 545 controls. IFN-gamma +874 T/A and TNF-alpha -308 G/A gene polymorphisms were genotyped via Allele Specific Oligonucleotide PCR (ASO-PCR) method. The results showed that the TNF-alpha -308 G/A polymorphism was more common in vitiligo patients than controls (P = 0.0004). This difference was only significant between female patients and controls (P < 0.0001), while there was no significant difference between male patients and male controls (P = 0.90). The distribution of IFN-gamma genotypes in vitiligo patients did not differ significantly from that in control subjects (P = 0.56). Since the presence of A nucleotide at position -308 of TNF-alpha gene is associated with increased cytokine production, therefore, the higher frequency of TNF-alpha -308 A allele in vitiligo patients compared to controls may be considered as a genetic susceptibility factor towards the development of vitiligo.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
1432-069X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
301
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
21-5
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| pubmed:meshHeading |
pubmed-meshheading:18820938-Adolescent,
pubmed-meshheading:18820938-Adult,
pubmed-meshheading:18820938-Aged,
pubmed-meshheading:18820938-Aged, 80 and over,
pubmed-meshheading:18820938-Child,
pubmed-meshheading:18820938-Female,
pubmed-meshheading:18820938-Gene Frequency,
pubmed-meshheading:18820938-Genetic Predisposition to Disease,
pubmed-meshheading:18820938-Humans,
pubmed-meshheading:18820938-Interferon-gamma,
pubmed-meshheading:18820938-Iran,
pubmed-meshheading:18820938-Male,
pubmed-meshheading:18820938-Middle Aged,
pubmed-meshheading:18820938-Polymorphism, Genetic,
pubmed-meshheading:18820938-Promoter Regions, Genetic,
pubmed-meshheading:18820938-Severity of Illness Index,
pubmed-meshheading:18820938-Sex Factors,
pubmed-meshheading:18820938-Tumor Necrosis Factor-alpha,
pubmed-meshheading:18820938-Vitiligo
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients.
|
| pubmed:affiliation |
Department of Dermatology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|