rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-1
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pubmed:abstractText |
Tumor necrosis factor-alpha (TNF-alpha) is an inflammatory cytokine involved in atherogenesis. Adipose tissue is an important source of endogenous TNF-alpha production. Pioglitazone, a member of the thiazolidinediones (TZDs), has anti-inflammatory and anti-atherogenic properties, while underlying mechanism has not been fully elucidated. The aim of this study was to evaluate the effect of pioglitazone on TNF-alpha serum concentration and mRNA expressions of subcutaneous adipose tissue in hypercholesterolemic rabbits.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/pioglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1874-1754
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-6
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pubmed:meshHeading |
pubmed-meshheading:18809217-Adipocytes,
pubmed-meshheading:18809217-Animals,
pubmed-meshheading:18809217-Blood Glucose,
pubmed-meshheading:18809217-Body Weight,
pubmed-meshheading:18809217-Cells, Cultured,
pubmed-meshheading:18809217-Cholesterol, Dietary,
pubmed-meshheading:18809217-Cholesterol, LDL,
pubmed-meshheading:18809217-Gene Expression,
pubmed-meshheading:18809217-Hypercholesterolemia,
pubmed-meshheading:18809217-Hypoglycemic Agents,
pubmed-meshheading:18809217-Lipopolysaccharides,
pubmed-meshheading:18809217-Male,
pubmed-meshheading:18809217-RNA, Messenger,
pubmed-meshheading:18809217-Rabbits,
pubmed-meshheading:18809217-Subcutaneous Fat,
pubmed-meshheading:18809217-Thiazolidinediones,
pubmed-meshheading:18809217-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Pioglitazone reduces tumor necrosis factor-alpha serum concentration and mRNA expression of adipose tissue in hypercholesterolemic rabbits.
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pubmed:affiliation |
Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren-Min road No 139, Changsha, Hunan 410011, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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