|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0027270,
umls-concept:C0033268,
umls-concept:C0080194,
umls-concept:C0162638,
umls-concept:C0225336,
umls-concept:C0439596,
umls-concept:C0812281,
umls-concept:C0851827,
umls-concept:C1280500,
umls-concept:C1658143,
umls-concept:C1701901,
umls-concept:C1711351
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-2-27
|
|
pubmed:abstractText |
Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase. NAD(P)H oxidase subunit p22phox is reported to be related to the development of atherosclerosis and increased levels of p22phox mRNA are correlated to ECs proliferation. However, the importance and signaling mechanism of p22phox on ECs survival and angiogenesis under cyclic strain are unclear.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CYBA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1095-9319
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
77
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
125-33
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18801380-Apoptosis,
pubmed-meshheading:18801380-Base Sequence,
pubmed-meshheading:18801380-Biomechanics,
pubmed-meshheading:18801380-Cell Line,
pubmed-meshheading:18801380-Cell Survival,
pubmed-meshheading:18801380-DNA Primers,
pubmed-meshheading:18801380-Endothelial Cells,
pubmed-meshheading:18801380-Hemorheology,
pubmed-meshheading:18801380-Humans,
pubmed-meshheading:18801380-NADPH Oxidase,
pubmed-meshheading:18801380-Neovascularization, Physiologic,
pubmed-meshheading:18801380-Nitric Oxide,
pubmed-meshheading:18801380-Nitric Oxide Synthase Type III,
pubmed-meshheading:18801380-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18801380-RNA, Small Interfering,
pubmed-meshheading:18801380-Reactive Oxygen Species,
pubmed-meshheading:18801380-Signal Transduction,
pubmed-meshheading:18801380-Stress, Mechanical,
pubmed-meshheading:18801380-Tissue Culture Techniques
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox.
|
|
pubmed:affiliation |
Clinical Pharmacology and Therapeutics, Clinical Science Research Institute, Warwick Medical School, University of Warwick, CV2 2DX, UK. koubaijun@yahoo.com
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
