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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-10-14
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pubmed:abstractText |
COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k/Akt in these processes. The results showed that COX-2 increased the cells viability, migration and augment the number of CAOV-3. LY294002 could reduce COX-2 induce cells viability, migration and proliferation. These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1532-4192
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
822-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18798061-Cell Division,
pubmed-meshheading:18798061-Cell Line, Tumor,
pubmed-meshheading:18798061-Cell Movement,
pubmed-meshheading:18798061-Cell Survival,
pubmed-meshheading:18798061-Chromones,
pubmed-meshheading:18798061-Cyclooxygenase 2,
pubmed-meshheading:18798061-DNA Replication,
pubmed-meshheading:18798061-Female,
pubmed-meshheading:18798061-Humans,
pubmed-meshheading:18798061-Morpholines,
pubmed-meshheading:18798061-Neoplasm Proteins,
pubmed-meshheading:18798061-Ovarian Neoplasms,
pubmed-meshheading:18798061-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18798061-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18798061-RNA, Messenger,
pubmed-meshheading:18798061-RNA, Neoplasm,
pubmed-meshheading:18798061-RNA, Small Interfering,
pubmed-meshheading:18798061-Recombinant Fusion Proteins,
pubmed-meshheading:18798061-Signal Transduction,
pubmed-meshheading:18798061-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation.
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pubmed:affiliation |
Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China.
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pubmed:publicationType |
Journal Article
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