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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-9-15
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pubmed:abstractText |
Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in renal fibrogenesis. Small interfering RNA (siRNA) is an effective tool to silence gene expression. This study determined whether caudal vein injection of siRNA targeting CTGF inhibited its expression in rat kidneys in vivo, and furthermore whether it protected the kidney from renal fibrosis in chronic allograft nephropathy (CAN).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1345
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2365-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18790236-Animals,
pubmed-meshheading:18790236-Connective Tissue Growth Factor,
pubmed-meshheading:18790236-Disease Models, Animal,
pubmed-meshheading:18790236-Fibrosis,
pubmed-meshheading:18790236-Immediate-Early Proteins,
pubmed-meshheading:18790236-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18790236-Kidney,
pubmed-meshheading:18790236-Kidney Transplantation,
pubmed-meshheading:18790236-Male,
pubmed-meshheading:18790236-RNA, Small Interfering,
pubmed-meshheading:18790236-Rats,
pubmed-meshheading:18790236-Rats, Inbred F344,
pubmed-meshheading:18790236-Rats, Inbred Lew,
pubmed-meshheading:18790236-Transplantation, Homologous
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy.
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pubmed:affiliation |
Transplantation Institute, West China Hospital, Sichuan University, Chengdu, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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