Source:http://linkedlifedata.com/resource/pubmed/id/18782261
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-9-10
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| pubmed:abstractText |
Type 1 diabetes (T1D) is considered to be a T-cell-mediated autoimmune disease in which genetic predisposition is affected by HLA class II alleles and polymorphisms in cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene. We tested the hypothesis whether these T1D-related gene polymorphisms modulate cytokine response and thus contribute to the development of autoimmunity. The study includes 67 non-diabetic children, typed for HLA class II alleles and CTLA-4 polymorphisms (+49A/G, CT60A/G, CTBC217_1C/T). We measured cytokine secretion of peripheral blood mononuclear cells after stimulation with tetanus toxoid (TT), polio virus, coxsackie virus B4, pertussis toxin (PT) and phytohemagglutinin (PHA). We saw higher IL-13 response to TT in individuals with DR3-DQ2 haplotype (P = 0.002). HLA class II protective haplotype, DR2-DQ6, showed association with increased production of IFN-gamma (P < 0.001) and IL-2 (P = 0.005) in response to polio virus. In children with the autoimmunity-related homozygous genotypes CTLA-4 +49G/G, CT60G/G and CTBC217_1T/T, we found enhanced PT- and PHA-induced IFN-gamma production (P < 0.05). The cytokine responses to studied antigens were weakly modified by HLA class II risk haplotypes, and children with T1D-associated HLA risk haplotypes are not specifically inclined to develop an immune response in general. Higher IFN-gamma and IL-2 response to enterovirus in children with HLA class II protective haplotype DR2-DQ6 could be of importance in the protection from T1D-associated enterovirus infections. All autoimmunity related CTLA-4 polymorphisms were associated with enhanced IFN-gamma. This suggests impaired downregulation of cellular immunity by these CTLA-4 polymorphisms.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ alpha-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQA1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1365-3083
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
68
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
345-50
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18782261-Alleles,
pubmed-meshheading:18782261-Antigens, CD,
pubmed-meshheading:18782261-CTLA-4 Antigen,
pubmed-meshheading:18782261-Cells, Cultured,
pubmed-meshheading:18782261-Child, Preschool,
pubmed-meshheading:18782261-Cohort Studies,
pubmed-meshheading:18782261-Cytokines,
pubmed-meshheading:18782261-Diabetes Mellitus, Type 1,
pubmed-meshheading:18782261-Down-Regulation,
pubmed-meshheading:18782261-Genetic Predisposition to Disease,
pubmed-meshheading:18782261-Genotype,
pubmed-meshheading:18782261-HLA Antigens,
pubmed-meshheading:18782261-HLA-DQ Antigens,
pubmed-meshheading:18782261-HLA-DQ alpha-Chains,
pubmed-meshheading:18782261-HLA-DQ beta-Chains,
pubmed-meshheading:18782261-HLA-DR Antigens,
pubmed-meshheading:18782261-HLA-DRB1 Chains,
pubmed-meshheading:18782261-Homozygote,
pubmed-meshheading:18782261-Humans,
pubmed-meshheading:18782261-Leukocytes, Mononuclear,
pubmed-meshheading:18782261-Polymorphism, Genetic,
pubmed-meshheading:18782261-Random Allocation,
pubmed-meshheading:18782261-Sweden
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| pubmed:year |
2008
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| pubmed:articleTitle |
Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.
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| pubmed:affiliation |
Division of Pediatrics and Diabetes Research Center, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. jenny.wallden@imk.liu.se
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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