|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0038585,
umls-concept:C0086418,
umls-concept:C0164209,
umls-concept:C0205225,
umls-concept:C0334227,
umls-concept:C0338106,
umls-concept:C0441472,
umls-concept:C0534609,
umls-concept:C0685938,
umls-concept:C1171362,
umls-concept:C1314939,
umls-concept:C1515670,
umls-concept:C1704242
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|
pubmed:issue |
4
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|
pubmed:dateCreated |
2008-9-26
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|
pubmed:abstractText |
It has been demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonist L-733,060 induces cell proliferation and inhibition, respectively, in several human cancer cell lines. At present, it is unknown whether such actions are exerted on human gastric and colon adenocarcinomas. We carried out an in vitro study of the growth-inhibitory capacity of L-733,060 against human gastric and colon adenocarcinomas.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
1423-0380
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-54
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pubmed:meshHeading |
pubmed-meshheading:18781096-Adenocarcinoma,
pubmed-meshheading:18781096-Antineoplastic Agents,
pubmed-meshheading:18781096-Apoptosis,
pubmed-meshheading:18781096-Cell Line, Tumor,
pubmed-meshheading:18781096-Colonic Neoplasms,
pubmed-meshheading:18781096-Dose-Response Relationship, Drug,
pubmed-meshheading:18781096-Humans,
pubmed-meshheading:18781096-Immunohistochemistry,
pubmed-meshheading:18781096-Mitogens,
pubmed-meshheading:18781096-Piperidines,
pubmed-meshheading:18781096-Receptors, Neurokinin-1,
pubmed-meshheading:18781096-Stomach Neoplasms,
pubmed-meshheading:18781096-Substance P
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines.
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pubmed:affiliation |
Virgen del Rocío University Children's Hospital, Sevilla, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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