Source:http://linkedlifedata.com/resource/pubmed/id/18773665
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2008-9-8
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pubmed:abstractText |
Tumor necrosis factor alpha (TNF-alpha) is a principal cytokine that may induce weight loss. TNF-alpha -308 G to A polymorphism increases transcription of TNF-alpha in vitro. The aim of this study was to investigate whether TNF-alpha gene promoter polymorphism at position -308 (G to A substitution) is one of the factors playing a role in the development of anorexia nervosa (AN). Sixteen patients with AN, aged 11-20 years, were included in this study, and 5/16 (31%) patients had TNF-alpha -308 G/A genotype. In the control group, 12/174 (7%) had -308 G/A genotype. There was a significant statistical difference between the patient and control groups (p=0.007). The minimum body mass index (BMI) values ever recorded for each patient during the course of the disease were significantly higher in the five patients with TNF-alpha -308 G to A polymorphism (p= 0.003). TNF-alpha gene promoter polymorphism at position -308 might be associated with a predisposition to AN and initiate the disease. The protective mechanisms that affect clinical manifestation of the disease may be related with other anti-inflammatory cytokines or immunologic mechanisms.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0041-4301
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-22
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18773665-Adolescent,
pubmed-meshheading:18773665-Adult,
pubmed-meshheading:18773665-Anorexia Nervosa,
pubmed-meshheading:18773665-Child,
pubmed-meshheading:18773665-Female,
pubmed-meshheading:18773665-Genotype,
pubmed-meshheading:18773665-Humans,
pubmed-meshheading:18773665-Male,
pubmed-meshheading:18773665-Polymorphism, Genetic,
pubmed-meshheading:18773665-Promoter Regions, Genetic,
pubmed-meshheading:18773665-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Tumor necrosis factor alpha-308 gene polymorphism in patients with anorexia nervosa.
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pubmed:affiliation |
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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pubmed:publicationType |
Journal Article
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