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rdf:type |
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lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0040061,
umls-concept:C0040649,
umls-concept:C0079904,
umls-concept:C0597360,
umls-concept:C0752312,
umls-concept:C1366765,
umls-concept:C1366876,
umls-concept:C1370600,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1833235,
umls-concept:C1879547
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-19
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pubmed:abstractText |
We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acid Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thromboxane A2...,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0135
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
162-74
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18769070-Animals,
pubmed-meshheading:18769070-Cyclooxygenase Inhibitors,
pubmed-meshheading:18769070-Dose-Response Relationship, Drug,
pubmed-meshheading:18769070-Down-Regulation,
pubmed-meshheading:18769070-Male,
pubmed-meshheading:18769070-Mesenteric Arteries,
pubmed-meshheading:18769070-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:18769070-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:18769070-Muscle, Smooth, Vascular,
pubmed-meshheading:18769070-NF-kappa B,
pubmed-meshheading:18769070-Nitric Oxide Synthase,
pubmed-meshheading:18769070-Nucleic Acid Synthesis Inhibitors,
pubmed-meshheading:18769070-Organ Culture Techniques,
pubmed-meshheading:18769070-Phosphorylation,
pubmed-meshheading:18769070-Prostaglandin Antagonists,
pubmed-meshheading:18769070-Protein Kinase Inhibitors,
pubmed-meshheading:18769070-Protein Synthesis Inhibitors,
pubmed-meshheading:18769070-RNA, Messenger,
pubmed-meshheading:18769070-RNA Stability,
pubmed-meshheading:18769070-Rats,
pubmed-meshheading:18769070-Rats, Sprague-Dawley,
pubmed-meshheading:18769070-Receptors, Thromboxane A2, Prostaglandin H2,
pubmed-meshheading:18769070-Signal Transduction,
pubmed-meshheading:18769070-Time Factors,
pubmed-meshheading:18769070-Transcription, Genetic,
pubmed-meshheading:18769070-Vasoconstriction,
pubmed-meshheading:18769070-Vasoconstrictor Agents,
pubmed-meshheading:18769070-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Transcriptional down-regulation of thromboxane A(2) receptor expression via activation of MAPK ERK1/2, p38/NF-kappaB pathways.
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pubmed:affiliation |
Division of Experimental Vascular Research, Institute of Clinical Science in Lund, Lund University, Lund, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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