|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0032081,
umls-concept:C0032100,
umls-concept:C0040648,
umls-concept:C0079633,
umls-concept:C0079904,
umls-concept:C0205396,
umls-concept:C0429403,
umls-concept:C0567416,
umls-concept:C1280500,
umls-concept:C1417708,
umls-concept:C1423613,
umls-concept:C1522290,
umls-concept:C1539081,
umls-concept:C1704675,
umls-concept:C1705525,
umls-concept:C1707520
|
|
pubmed:dateCreated |
2008-9-19
|
|
pubmed:abstractText |
The transcription factor NF-kappaB is a very interesting target molecule for the design on anti-tumor, anti-inflammatory and pro-apoptotic drugs. However, the application of the widely-used molecular docking computational method for the virtual screening of chemical libraries on NF-kappaB is not yet reported in literature. Docking studies on a dataset of 27 molecules from extracts of two different medicinal plants to NF-kappaB-p50 were performed with the purpose of developing a docking protocol fit for the target under study.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-10212261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-10976530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-11160127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-12167479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-12446679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-12738678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-15027865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-15027866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-15124931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-15546742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-15788163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-16759101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-17466942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-18258920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-7830764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-9385547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18768082-9450761
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1472-6807
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
38
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:18768082-Aegle,
pubmed-meshheading:18768082-Animals,
pubmed-meshheading:18768082-Cattle,
pubmed-meshheading:18768082-Cell Line,
pubmed-meshheading:18768082-Cupressus,
pubmed-meshheading:18768082-DNA,
pubmed-meshheading:18768082-Gene Expression Regulation,
pubmed-meshheading:18768082-Humans,
pubmed-meshheading:18768082-Interleukin-8,
pubmed-meshheading:18768082-Models, Molecular,
pubmed-meshheading:18768082-NF-kappa B p50 Subunit,
pubmed-meshheading:18768082-Plant Extracts,
pubmed-meshheading:18768082-Plants, Medicinal,
pubmed-meshheading:18768082-Protein Binding,
pubmed-meshheading:18768082-Protein Conformation,
pubmed-meshheading:18768082-Pseudomonas,
pubmed-meshheading:18768082-RNA, Messenger
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression.
|
|
pubmed:affiliation |
BioPharmaNet, ER-GenTech, Department of Biochemistry and Molecular Biology, University of Ferrara, Italy. pcclra@unife.it
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
