Linked Life Data

18758472

Source:http://linkedlifedata.com/resource/pubmed/id/18758472

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-1-26
pubmed:abstractText
The tetraspanin transmembrane proteins have emerged as key players in malignancy, the immune system, during fertilization and infectious disease processes. Tetraspanins engage in a wide range of specific molecular interactions, occurring through the formation of tetraspanin-enriched microdomains (TEMs). TEMs therefore serve as a starting point for understanding how tetraspanins affect cell signalling, adhesion, morphology, motility, fusion and virus infection. An abundance of recent evidence suggests that targeting tetraspanins, for example, by monoclonal antibodies, soluble large-loop proteins or RNAi technology, should be therapeutically beneficial.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1474-1776
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
747-58
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Targeting of tetraspanin proteins--potential benefits and strategies.
pubmed:affiliation
Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachussetts 02115, USA. Martin_Hemler@dfci.harvard.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural