Linked Life Data

1874692

Source:http://linkedlifedata.com/resource/pubmed/id/1874692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-9-26
pubmed:abstractText
A liquid chromatographic method has been developed for the measurement of chloramphenicol (CAP) in muscle, liver, and kidney. The mean recovery levels were 82.6, 75.3, and 79.2% in muscle, liver, and kidney, respectively. The method was repeatable and reproducible for CAP measurement in muscle, with a detection limit of 1 microgram/kg. Investigation of CAP stability in muscle, liver, and kidney showed that CAP stability in muscle was good at -20 degrees C; for spiked liver and kidney, degradation of CAP was observed, and the use of piperonyl butoxide (PB) for metabolism inhibition was recommended for recovery and linearity studies. However, PB was unnecessary for preservation of treated animal tissues if samples were cut into cubes and cooled at -20 degrees C, just after slaughter, pending analysis. With these limitations, CAP can be measured in liver and kidney.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-5756
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Liquid chromatographic determination of chloramphenicol in calf tissues: studies of stability in muscle, kidney, and liver.
pubmed:affiliation
Laboratoire des Medicaments Vétérinaires, Centre National d'Etudes Vétérinaires et Alimentaires, Ministère de l'Agriculture et de la Forêt, La Haute Marche-Javené, Fougères.
pubmed:publicationType
Journal Article