Source:http://linkedlifedata.com/resource/pubmed/id/18685121
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2008-11-25
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| pubmed:abstractText |
The decrease in the copy number of mitochondrial DNA (mtDNA) in cancer tissues might be associated with a decrease in oxidative mtDNA damage to achieve cancer immortalization and progression. Lung cancer specimens were collected from 29 patients with stage III non-small cell lung cancer (NSCLC) after neoadjuvant chemotherapy followed by surgical resection. The relative mtDNA copy number and the oxidative mtDNA damage (formation of 8-OHdG in mtDNA) of each cancer tissue were measured by quantitative real-time PCR. Seven female and 22 male lung cancer patients, with a mean age of 63.5 years were evaluated. Tumors of five patients became progressive, 13 stable, and 11 partially responsive after preoperative chemotherapy. Low mtDNA copy number (P=0.089) and low degree of oxidative mtDNA damage (P=0.036) were found to associate with tumor progression. Moreover, mtDNA copy number was significantly related to the degree of oxidative mtDNA damage (P=0.031). The mtDNA copy number and oxidative mtDNA damage were lower in advanced NSCLC after chemotherapy. This finding suggests that a decrease in the content of mtDNA may result in a decrease of mitochondrial density in cancer cells, which leads to a decrease of endogenous ROS production and reduction of ROS-triggered DNA damage to achieve immortalization.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxy-2'-deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/gemcitabine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1569-9285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
954-8
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| pubmed:meshHeading |
pubmed-meshheading:18685121-Aged,
pubmed-meshheading:18685121-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18685121-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:18685121-Chemotherapy, Adjuvant,
pubmed-meshheading:18685121-Cisplatin,
pubmed-meshheading:18685121-DNA, Mitochondrial,
pubmed-meshheading:18685121-DNA Damage,
pubmed-meshheading:18685121-Deoxycytidine,
pubmed-meshheading:18685121-Deoxyguanosine,
pubmed-meshheading:18685121-Disease Progression,
pubmed-meshheading:18685121-Down-Regulation,
pubmed-meshheading:18685121-Female,
pubmed-meshheading:18685121-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18685121-Humans,
pubmed-meshheading:18685121-Lung Neoplasms,
pubmed-meshheading:18685121-Male,
pubmed-meshheading:18685121-Middle Aged,
pubmed-meshheading:18685121-Neoadjuvant Therapy,
pubmed-meshheading:18685121-Oxidative Stress,
pubmed-meshheading:18685121-Pneumonectomy,
pubmed-meshheading:18685121-Retrospective Studies,
pubmed-meshheading:18685121-Treatment Outcome
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| pubmed:year |
2008
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| pubmed:articleTitle |
Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy.
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| pubmed:affiliation |
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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