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rdf:type |
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lifeskim:mentions |
umls-concept:C0003864,
umls-concept:C0011209,
umls-concept:C0017337,
umls-concept:C0036043,
umls-concept:C0086022,
umls-concept:C0205276,
umls-concept:C0205390,
umls-concept:C0231491,
umls-concept:C0332256,
umls-concept:C0442335,
umls-concept:C1456820,
umls-concept:C1705099,
umls-concept:C2603343
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|
pubmed:issue |
8
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pubmed:dateCreated |
2009-7-16
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pubmed:abstractText |
To examine the safety and tolerability of a single intra-articular injection of rAAV2-TNFR:Fc, an adenoassociated virus serotype 2 vector containing the cDNA for the human tumour necrosis factor-immunoglobulin Fc fusion gene (tgAAC94), in subjects with inflammatory arthritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1468-2060
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1247-54
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pubmed:dateRevised |
2009-10-1
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pubmed:meshHeading |
pubmed-meshheading:18678578-Adult,
pubmed-meshheading:18678578-Aged,
pubmed-meshheading:18678578-Arthritis, Rheumatoid,
pubmed-meshheading:18678578-DNA, Complementary,
pubmed-meshheading:18678578-Dependovirus,
pubmed-meshheading:18678578-Double-Blind Method,
pubmed-meshheading:18678578-Feasibility Studies,
pubmed-meshheading:18678578-Female,
pubmed-meshheading:18678578-Gene Therapy,
pubmed-meshheading:18678578-Gene Transfer Techniques,
pubmed-meshheading:18678578-Genetic Vectors,
pubmed-meshheading:18678578-Humans,
pubmed-meshheading:18678578-Immunoglobulin G,
pubmed-meshheading:18678578-Injections, Intra-Articular,
pubmed-meshheading:18678578-Male,
pubmed-meshheading:18678578-Middle Aged,
pubmed-meshheading:18678578-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:18678578-Recombinant Fusion Proteins,
pubmed-meshheading:18678578-Severity of Illness Index,
pubmed-meshheading:18678578-Treatment Outcome,
pubmed-meshheading:18678578-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study.
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pubmed:affiliation |
Seattle Rheumatology Associates/Swedish Medical Center Research, Seattle, Washington, USA.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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