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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-8-7
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pubmed:abstractText |
The reduction of pain in the course of antiinflammatory therapy can result from an attenuation of the inflammatory process and/or from the neutralization of endogenous mediators of inflammation that act directly on nociceptive neurons. The purpose of this study was to investigate whether analgesic effects of the neutralization of tumor necrosis factor alpha (TNFalpha) are due to an attenuation of inflammation or whether direct neuronal effects significantly contribute to pain relief in the course of therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFR-Fc fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/infliximab
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2368-78
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pubmed:meshHeading |
pubmed-meshheading:18668541-Adjuvants, Immunologic,
pubmed-meshheading:18668541-Animals,
pubmed-meshheading:18668541-Antibodies, Monoclonal,
pubmed-meshheading:18668541-Antirheumatic Agents,
pubmed-meshheading:18668541-Arthralgia,
pubmed-meshheading:18668541-Arthritis, Experimental,
pubmed-meshheading:18668541-Disease Models, Animal,
pubmed-meshheading:18668541-Female,
pubmed-meshheading:18668541-Ganglia, Spinal,
pubmed-meshheading:18668541-Immunoglobulin G,
pubmed-meshheading:18668541-Knee Joint,
pubmed-meshheading:18668541-Nerve Fibers, Unmyelinated,
pubmed-meshheading:18668541-Neurons, Afferent,
pubmed-meshheading:18668541-Nociceptors,
pubmed-meshheading:18668541-Rats,
pubmed-meshheading:18668541-Rats, Inbred Lew,
pubmed-meshheading:18668541-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:18668541-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target.
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pubmed:affiliation |
University Hospital of Jena, Jena, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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