Source:http://linkedlifedata.com/resource/pubmed/id/18645461
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-7-22
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| pubmed:abstractText |
Individual variability in the production of tumor necrosis factor-alpha (TNF-alpha) has been attributed to genetic factors. We examined whether alleles of TNF gene (lymphotoxin-alpha+250, TNF-alpha-308, and TNF-alpha-238) affect tracheal aspirate fluid (TAF) levels of TNF-alpha among preterm infants at risk of bronchopulmonary dysplasia. TAF samples were collected within 48 h of birth and 7, 14, 21, and 28 d later. Haplotypes [designated using the nucleotide bases in the chromosome order (lymphotoxin-alpha+250, TNF-alpha-308, TNF-alpha-238)] of TNF were correlated with levels of TNF-alpha. Diplotypes of TNF (genotypes of haplotypes) classified as high, intermediate, or low based on their relation to TAF TNF-alpha levels were also correlated with TNF-alpha levels. The most frequent (and reference haplotype) was AGG. The GGG haplotype was associated with the lowest TAF TNF-alpha levels on day 7 among African American infants (p < 0.008). Sequential changes in levels of TNF-alpha correlated with infants' diplotype status [high (HH), intermediate (HL), low (LL)]. Fetal chorioamnionitis but not bronchopulmonary dysplasia was associated with infants' diplotypes (p < 0.005). Haplotypes of the TNF gene influence TAF levels of TNF-alpha. Diplotypes of TNF are associated with fetal chorioamnionitis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0031-3998
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
64
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
165-70
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| pubmed:meshHeading |
pubmed-meshheading:18645461-Bronchopulmonary Dysplasia,
pubmed-meshheading:18645461-Chorioamnionitis,
pubmed-meshheading:18645461-Female,
pubmed-meshheading:18645461-Gene Frequency,
pubmed-meshheading:18645461-Genotype,
pubmed-meshheading:18645461-Haplotypes,
pubmed-meshheading:18645461-Humans,
pubmed-meshheading:18645461-Infant, Newborn,
pubmed-meshheading:18645461-Infant, Premature,
pubmed-meshheading:18645461-Male,
pubmed-meshheading:18645461-Pregnancy,
pubmed-meshheading:18645461-Risk Factors,
pubmed-meshheading:18645461-Suction,
pubmed-meshheading:18645461-Trachea,
pubmed-meshheading:18645461-Tumor Necrosis Factor-alpha
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| pubmed:year |
2008
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| pubmed:articleTitle |
Haplotypes of tumor necrosis factor gene and tracheal aspirate fluid levels of tumor necrosis factor-alpha in preterm infants.
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| pubmed:affiliation |
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA. nkazzi@med.wayne.edu
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| pubmed:publicationType |
Journal Article
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