|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
2008-7-18
|
|
pubmed:abstractText |
The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other. Tag is a nuclear protein even in the absence of IRS-1, but IRS-1 is required for occupancy and activation by Tag of the ribosomal DNA (rDNA), cyclin D1 and c-myc promoters. Our results indicate that IRS-1 plays a significant role in Tag activation of cell cycle progression genes.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Polyomavirus Transforming,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/IRS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MYC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1551-4005
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1999-2002
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18642444-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18642444-Antigens, Polyomavirus Transforming,
pubmed-meshheading:18642444-Cell Cycle,
pubmed-meshheading:18642444-Cell Line, Tumor,
pubmed-meshheading:18642444-Cyclin D1,
pubmed-meshheading:18642444-DNA, Ribosomal,
pubmed-meshheading:18642444-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18642444-Humans,
pubmed-meshheading:18642444-Insulin Receptor Substrate Proteins,
pubmed-meshheading:18642444-Promoter Regions, Genetic,
pubmed-meshheading:18642444-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:18642444-Simian virus 40
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
The role of insulin receptor substrate-1 in the oncogenicity of simian virus 40 T antigen.
|
|
pubmed:affiliation |
Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
