Source:http://linkedlifedata.com/resource/umls/id/C0123658
NCI: The protein IRS1 acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/IGF1-stimulated glucose transport. (from OMIM 600797)