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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-8-4
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pubmed:abstractText |
Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinflammatory cytokine involved in RF and other autoimmune diseases. Polymorphisms in the promoter region of the TNFA gene have been associated with RF. Given the association between OCD and RF, the goal of the present study was to investigate a possible association between polymorphisms within the promoter region of TNFA and OCD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3940
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pubmed:author |
pubmed-author:CappiCarolinaC,
pubmed-author:CordeiroQuirinoQ,
pubmed-author:GoldbergAnna CarlaAC,
pubmed-author:GuilhermeLuizaL,
pubmed-author:HounieAna GabrielaAG,
pubmed-author:KalilJorgeJ,
pubmed-author:Machado-LimaArianeA,
pubmed-author:MiguelEurípedes ConstantinoEC,
pubmed-author:MoraesIvanilI,
pubmed-author:NakanoEduardoE,
pubmed-author:PaláciosSelma ASA,
pubmed-author:PaulsDavidD,
pubmed-author:PereiraCarlos Alberto BCA,
pubmed-author:RosárioMaria Conceição doMC,
pubmed-author:SampaioAline SantosAS,
pubmed-author:ValladaHomero PintoHP
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
442
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-90
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pubmed:meshHeading |
pubmed-meshheading:18639610-Adult,
pubmed-meshheading:18639610-Brazil,
pubmed-meshheading:18639610-Case-Control Studies,
pubmed-meshheading:18639610-Female,
pubmed-meshheading:18639610-Gene Frequency,
pubmed-meshheading:18639610-Genetic Predisposition to Disease,
pubmed-meshheading:18639610-Genotype,
pubmed-meshheading:18639610-Humans,
pubmed-meshheading:18639610-Male,
pubmed-meshheading:18639610-Obsessive-Compulsive Disorder,
pubmed-meshheading:18639610-Polymorphism, Genetic,
pubmed-meshheading:18639610-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
TNF-alpha polymorphisms are associated with obsessive-compulsive disorder.
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pubmed:affiliation |
Department of Psychiatry, Institute of Psychiatry, Clinical Hospital, University of São Paulo (USP), Brazil. anah@protoc.com.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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