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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-8-7
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pubmed:abstractText |
A complex of three cell adhesion molecules (CAMs) Neurexin IV(Nrx IV), Contactin (Cont) and Neuroglian (Nrg) is implicated in the formation of septate junctions between epithelial cells in Drosophila. These CAMs are interdependent for their localization at septate junctions and e.g. null mutation of nrx IV or cont induces the mislocalization of Nrg to the baso-lateral membrane. These mutations also result in ultrastructural alteration of the strands of septate junctions and breakdown of the paracellular barrier. Varicose (Vari) and Coracle (Cora), that both interact with the cytoplasmic tail of Nrx IV, are scaffolding molecules required for the formation of septate junctions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-10662501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-10769038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-11395000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-11742088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12367625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12500940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12542678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12558984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12651952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12782686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-12972410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-14536062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-14573348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-14623435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-14681183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-14734539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-15458577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-15459097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-15556867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-16213218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-16943624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-17032735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-17194782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-17267446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-2805067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-8159755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-8162854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-8314002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-8636238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-8830775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-8978610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-9508778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-9660878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18638384-9786343
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/Contactins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nrg protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Nrx protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Varicose protein, Drososphila,
http://linkedlifedata.com/resource/pubmed/chemical/cora protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2121
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18638384-Animals,
pubmed-meshheading:18638384-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:18638384-Cell Line, Tumor,
pubmed-meshheading:18638384-Cell Membrane,
pubmed-meshheading:18638384-Contactins,
pubmed-meshheading:18638384-Drosophila,
pubmed-meshheading:18638384-Drosophila Proteins,
pubmed-meshheading:18638384-Epithelial Cells,
pubmed-meshheading:18638384-Guanylate Cyclase,
pubmed-meshheading:18638384-Intercellular Junctions,
pubmed-meshheading:18638384-Membrane Proteins,
pubmed-meshheading:18638384-Models, Biological,
pubmed-meshheading:18638384-Photobleaching,
pubmed-meshheading:18638384-Recombinant Fusion Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila.
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pubmed:affiliation |
Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 6231 CNRS, Marseille, France. monique.laval@univmed.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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