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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-7
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pubmed:abstractText |
Central nervous system plasticity is essential for normal function, but can also reinforce abnormal network behavior, leading to epilepsy and other disorders. The role of altered ion channel expression in abnormal plasticity has not been thoroughly investigated. Nav1.6 is the most abundantly expressed sodium channel in the nervous system. Because of its distribution in the cell body and axon initial segment, Nav1.6 is crucial for action potential generation. The goal of the present study was to investigate the possible role of changes in Nav1.6 expression in abnormal, activity-dependent plasticity of hippocampal circuits.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-1167
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
44-55
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pubmed:meshHeading |
pubmed-meshheading:18637833-Animals,
pubmed-meshheading:18637833-Disease Progression,
pubmed-meshheading:18637833-Epilepsy,
pubmed-meshheading:18637833-Hippocampus,
pubmed-meshheading:18637833-Immunohistochemistry,
pubmed-meshheading:18637833-In Situ Hybridization,
pubmed-meshheading:18637833-Kindling, Neurologic,
pubmed-meshheading:18637833-Nerve Tissue Proteins,
pubmed-meshheading:18637833-Patch-Clamp Techniques,
pubmed-meshheading:18637833-RNA, Messenger,
pubmed-meshheading:18637833-Rats,
pubmed-meshheading:18637833-Rats, Sprague-Dawley,
pubmed-meshheading:18637833-Sodium Channels
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pubmed:year |
2009
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pubmed:articleTitle |
Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis.
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pubmed:affiliation |
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA. hal.blumenfeld@yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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