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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-7-23
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pubmed:abstractText |
As HIV-specific cytotoxic T cells play a key role during acute and chronic HIV-1 infection in humans, the ability of potential anti-HIV vaccines to elicit strong, broad T cell responses is likely to be crucial. The HIV-1 Gag antigen is widely considered a relevant antigen for the development of an anti-HIV vaccine since it is one of the most conserved viral proteins and is also known to induce T cell responses. In the majority of studies reporting Gag-specific cellular immune responses induced by Gag-based vaccines, only a small number of Gag T cell epitopes were tested in preclinical mouse models, thus giving an incomplete picture of the numerous possible cellular immune responses against this antigen. As is, this partial knowledge of epitope-specific T cell responses directed to Gag will unavoidably result in a limited preclinical evaluation of Gag-based vaccines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-10415046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-11035060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-11751963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-16243561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-1709722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-17182686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-17312117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-17892849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-17893201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-18096278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-4547543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-7890324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-8416373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-9367954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-9516110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18625037-9743362
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18625037-AIDS Vaccines,
pubmed-meshheading:18625037-Amino Acid Sequence,
pubmed-meshheading:18625037-Animals,
pubmed-meshheading:18625037-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:18625037-Epitope Mapping,
pubmed-meshheading:18625037-Epitopes, T-Lymphocyte,
pubmed-meshheading:18625037-Gene Products, gag,
pubmed-meshheading:18625037-Gene Products, tat,
pubmed-meshheading:18625037-HIV Infections,
pubmed-meshheading:18625037-HIV-1,
pubmed-meshheading:18625037-Mice,
pubmed-meshheading:18625037-Mice, Inbred BALB C,
pubmed-meshheading:18625037-Molecular Sequence Data,
pubmed-meshheading:18625037-Peptides,
pubmed-meshheading:18625037-T-Lymphocytes, Cytotoxic
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pubmed:year |
2008
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pubmed:articleTitle |
Identification of new HIV-1 Gag-specific cytotoxic T lymphocyte responses in BALB/c mice.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Via L, Borsari 46, University of Ferrara, 44100, Ferrara, Italy. silvia.cellini@unife.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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