Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-9-9
pubmed:abstractText
The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male. We report a female patient with acute myeloid leukemia (AML) initially presenting with normal karyotype and negative HLA-DR expression who achieved complete remission after standard chemotherapy. The disease relapsed 7 months later with cytogenetic change of t(8;9)(p22;p24). Flow cytometry analysis showed evolutional change of immunophenotype from negative to positive HLA-DR expression and fluorescence in situ hybridization (FISH) analysis demonstrated a PCM1-JAK2 fusion gene. We speculate that the cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0925-5710
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-201
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18594780-Autoantigens, pubmed-meshheading:18594780-Cell Cycle Proteins, pubmed-meshheading:18594780-Chromosome Aberrations, pubmed-meshheading:18594780-Chromosomes, Human, Pair 8, pubmed-meshheading:18594780-Chromosomes, Human, Pair 9, pubmed-meshheading:18594780-Fatal Outcome, pubmed-meshheading:18594780-Female, pubmed-meshheading:18594780-Flow Cytometry, pubmed-meshheading:18594780-Gene Expression Regulation, Leukemic, pubmed-meshheading:18594780-HLA-DR Antigens, pubmed-meshheading:18594780-Humans, pubmed-meshheading:18594780-Immunophenotyping, pubmed-meshheading:18594780-Janus Kinase 2, pubmed-meshheading:18594780-Leukemia, Myeloid, Acute, pubmed-meshheading:18594780-Middle Aged, pubmed-meshheading:18594780-Oncogene Proteins, Fusion, pubmed-meshheading:18594780-Recurrence, pubmed-meshheading:18594780-Translocation, Genetic
pubmed:year
2008
pubmed:articleTitle
Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia.
pubmed:affiliation
Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC.
pubmed:publicationType
Journal Article, Case Reports