Linked Life Data

18579072

Source:http://linkedlifedata.com/resource/pubmed/id/18579072

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-6-26
pubmed:abstractText
Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1097-4199
pubmed:author
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
825-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
In search of the holy grail for Drosophila TRP.
pubmed:affiliation
Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. cmontell@jhmi.edu
pubmed:publicationType
Journal Article, Comment, Review