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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0162371,
umls-concept:C0162597,
umls-concept:C0185117,
umls-concept:C0301944,
umls-concept:C1332710,
umls-concept:C1332823,
umls-concept:C1704675,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2008-8-22
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pubmed:abstractText |
Transplantation of hematopoietic stem cells (HSCs) is usually accomplished through intravenous injection, a complex process that requires recognition of bone marrow vasculature and migration to a supportive microenvironment. Hence, some populations of HSCs, including cord blood (CB) Lin(-)CD34(-) stem cells, do not engraft well in bone marrow (BM) of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. In this study, we examined the effect of human stromal interactions on the properties of CB Lin(-)CD34(-) cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DKK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1121-31
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pubmed:meshHeading |
pubmed-meshheading:18562079-Animals,
pubmed-meshheading:18562079-Antigens, CD34,
pubmed-meshheading:18562079-Antigens, Differentiation,
pubmed-meshheading:18562079-Bone Marrow,
pubmed-meshheading:18562079-Cell Communication,
pubmed-meshheading:18562079-Chemotaxis, Leukocyte,
pubmed-meshheading:18562079-Coculture Techniques,
pubmed-meshheading:18562079-Fetal Blood,
pubmed-meshheading:18562079-Graft Survival,
pubmed-meshheading:18562079-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:18562079-Hematopoietic Stem Cells,
pubmed-meshheading:18562079-Humans,
pubmed-meshheading:18562079-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18562079-Mice,
pubmed-meshheading:18562079-Mice, Inbred NOD,
pubmed-meshheading:18562079-Mice, SCID,
pubmed-meshheading:18562079-Receptors, CXCR4,
pubmed-meshheading:18562079-Solubility,
pubmed-meshheading:18562079-Stromal Cells,
pubmed-meshheading:18562079-Transplantation, Heterologous,
pubmed-meshheading:18562079-Up-Regulation,
pubmed-meshheading:18562079-Wnt Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells.
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pubmed:affiliation |
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. mkobune@sapmed.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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