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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-22
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pubmed:abstractText |
We tested the hypothesis that the 5HT(1D)R, the primary antinociceptive target of triptans, is differentially distributed in tissues responsible for migraine pain. The density of 5HT(1D)R was quantified in tissues obtained from adult female rats with Western blot analysis. Receptor location was assessed with immunohistochemistry. The density of 5HT(1D)R was significantly greater in tissues known to produce migraine-like pain (i.e. circle of Willis and dura) than in structures in which triptans have no antinociceptive efficacy (i.e. temporalis muscle). 5HT(1D)R-like immunoreactivity was restricted to neuronal fibres, where it colocalized with calcitonin gene-related peptide and tyrosine hydroxylase immunoreactive fibres. These results are consistent with our hypothesis that the limited therapeutic profile of triptans could reflect its differential peripheral distribution and that the antinociceptive efficacy reflects inhibition of neuropeptide release from sensory afferents. An additional site of action at sympathetic efferents is also suggested.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-10212302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-11323131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-11422450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-11437896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-11478927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-12466238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-1352173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-14581653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-14645495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-14673512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-14705109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-15016917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-15306203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-16472334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-16516890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-1663596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-1682049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-17405136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-1761750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-2034661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-2285266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-2502607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8320095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8388188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8545150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8700126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8744664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8955268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-8978753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9169294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9170336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9209117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9414008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9453271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9559906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9607720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18557979-9950621
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1468-2982
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
933-44
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18557979-Afferent Pathways,
pubmed-meshheading:18557979-Animals,
pubmed-meshheading:18557979-Blotting, Western,
pubmed-meshheading:18557979-Calcitonin,
pubmed-meshheading:18557979-Carotid Artery, Common,
pubmed-meshheading:18557979-Circle of Willis,
pubmed-meshheading:18557979-Dura Mater,
pubmed-meshheading:18557979-Facial Pain,
pubmed-meshheading:18557979-Female,
pubmed-meshheading:18557979-Migraine Disorders,
pubmed-meshheading:18557979-Nerve Fibers,
pubmed-meshheading:18557979-Nerve Tissue Proteins,
pubmed-meshheading:18557979-Organ Specificity,
pubmed-meshheading:18557979-Protein Precursors,
pubmed-meshheading:18557979-Rats,
pubmed-meshheading:18557979-Rats, Sprague-Dawley,
pubmed-meshheading:18557979-Receptor, Serotonin, 5-HT1D,
pubmed-meshheading:18557979-Serotonin Receptor Agonists,
pubmed-meshheading:18557979-Superior Cervical Ganglion,
pubmed-meshheading:18557979-Trigeminal Ganglion,
pubmed-meshheading:18557979-Tryptamines,
pubmed-meshheading:18557979-Tyrosine 3-Monooxygenase
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pubmed:year |
2008
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pubmed:articleTitle |
Serotonin type 1D receptors (5HTR) are differentially distributed in nerve fibres innervating craniofacial tissues.
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pubmed:affiliation |
Department of Biomedical Sciences and Medical Sciences Training Program, University of Maryland, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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