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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-8-19
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pubmed:abstractText |
Surgical specimens from 19 patients with invasive colorectal cancers and 12 specimens of normal mucosa from the same patients were examined immunohistochemically for the production of the immunoreactive (IR-) transforming growth factor (TGF)-alpha and IR-epidermal growth factor (EGF) with an anti-TGF-alpha monoclonal antibody (MAb) OAL-MTG01 and anti-EGF MAb KEM-10. Immunoreactive TGF-alpha was detected in 16 (84.2%) of 19 colorectal cancers. In contrast, there was no IR-TGF-alpha in the gland cells of normal mucosa. Immunoreactive EGF was detected in 7 (36.8%) of 19 colorectal cancers and 1 (8.3%) of 12 cases of normal mucosa. The production of both IR-TGF-alpha and IR-EGF in colorectal cancer did not differ by histologic type and Dukes' stage. Immunoreactive TGF-alpha was detected at significantly higher incidence than IR-EGF in colorectal cancer. These results indicate that IR-TGF-alpha should prove valuable as a possible tumor marker in colorectal cancers, and it may be very useful in understanding the biology of colorectal cancer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-1698444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2442615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2446740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2541895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2544769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2647276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2720695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2736210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2783462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2887281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-2925270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-3002610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-3044605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-3121543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-3155699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-3282475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-3883191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-4601890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1853928-6166661
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1991
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pubmed:articleTitle |
Immunoreactive transforming growth factor alpha is commonly present in colorectal neoplasia.
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pubmed:affiliation |
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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