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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-8-21
|
| pubmed:abstractText |
We investigate a model of normal tissue complication probability for tissues that may be represented by a critical element architecture. We derive formulas for complication probability that apply to both a partial volume irradiation and to an arbitrary inhomogeneous dose distribution. The dose-volume isoeffect relationship which is a consequence of a critical element architecture is discussed and compared to the empirical power law relationship. A dose-volume histogram reduction scheme for a "pure" critical element model is derived. In addition, a point-based algorithm which does not require precomputation of a dose-volume histogram is derived. The existing published dose-volume histogram reduction algorithms are analyzed. We show that the existing algorithms, developed empirically without an explicit biophysical model, have a close relationship to the critical element model at low levels of complication probability. However, we also show that they have aspects which are not compatible with a critical element model and we propose a modification to one of them to circumvent its restriction to low complication probabilities.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0167-8140
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
166-76
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1852908-Algorithms,
pubmed-meshheading:1852908-Dose-Response Relationship, Radiation,
pubmed-meshheading:1852908-Humans,
pubmed-meshheading:1852908-Mathematical Computing,
pubmed-meshheading:1852908-Models, Statistical,
pubmed-meshheading:1852908-Probability,
pubmed-meshheading:1852908-Radiation Injuries
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Calculation of normal tissue complication probability and dose-volume histogram reduction schemes for tissues with a critical element architecture.
|
| pubmed:affiliation |
Department of Radiation Medicine, Massachusetts General Hospital, Boston 02114.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|