|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0000744,
umls-concept:C0079395,
umls-concept:C0080279,
umls-concept:C0080298,
umls-concept:C0087111,
umls-concept:C0237477,
umls-concept:C0242608,
umls-concept:C1412097,
umls-concept:C1455147,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1826328,
umls-concept:C1999216,
umls-concept:C2266681
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2008-8-1
|
|
pubmed:abstractText |
Dasatinib is a multitargeted inhibitor of ABL, the SRC family, and other tyrosine kinases. We sought to evaluate the effects of this drug on cell proliferation, centrosomes, mitotic spindles, and cell cycle progression in vitro and in vivo.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1592-8721
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
93
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1145-54
|
|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:18519516-Animals,
pubmed-meshheading:18519516-Antineoplastic Agents,
pubmed-meshheading:18519516-Bone Marrow Cells,
pubmed-meshheading:18519516-CHO Cells,
pubmed-meshheading:18519516-Cell Division,
pubmed-meshheading:18519516-Cell Line, Tumor,
pubmed-meshheading:18519516-Centrosome,
pubmed-meshheading:18519516-Cricetinae,
pubmed-meshheading:18519516-Cricetulus,
pubmed-meshheading:18519516-Fibroblasts,
pubmed-meshheading:18519516-G1 Phase,
pubmed-meshheading:18519516-Genes, abl,
pubmed-meshheading:18519516-Genes, src,
pubmed-meshheading:18519516-Humans,
pubmed-meshheading:18519516-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:18519516-Osteosarcoma,
pubmed-meshheading:18519516-Piperazines,
pubmed-meshheading:18519516-Pyrimidines,
pubmed-meshheading:18519516-Skin Physiological Phenomena
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Centrosome aberrations and G1 phase arrest after in vitro and in vivo treatment with the SRC/ABL inhibitor dasatinib.
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|
pubmed:affiliation |
III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Wiesbadener Strasse 7-11, 68305 Mannheim, Germany. alice.fabarius@med3.ma.uni-heidelberg.de
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
