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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-7-28
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pubmed:abstractText |
Bone marrow-derived liver stem cells (BDLSCs) are very robust cells that can differentiate into liver epithelial cells. These stem cells are promising targets for gene therapy treatment of liver diseases. Liver fibrosis results from chronic liver damage characterized by an accumulation of extracellular matrix (ECM) and levels of urokinase-type plasminogen activator (uPA) play an important role in ECM degradation. In the present study, we investigated the therapeutic effects of uPA gene-modified BDLSC transplantation on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1521-2254
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2008 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-66
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18481824-Adenoviridae,
pubmed-meshheading:18481824-Animals,
pubmed-meshheading:18481824-Bile Ducts,
pubmed-meshheading:18481824-Bone Marrow Cells,
pubmed-meshheading:18481824-Carbon Tetrachloride,
pubmed-meshheading:18481824-Cell Differentiation,
pubmed-meshheading:18481824-Cell Proliferation,
pubmed-meshheading:18481824-Cells, Cultured,
pubmed-meshheading:18481824-Female,
pubmed-meshheading:18481824-Gene Therapy,
pubmed-meshheading:18481824-Genetic Vectors,
pubmed-meshheading:18481824-Green Fluorescent Proteins,
pubmed-meshheading:18481824-Immunohistochemistry,
pubmed-meshheading:18481824-Ligation,
pubmed-meshheading:18481824-Liver,
pubmed-meshheading:18481824-Liver Cirrhosis, Experimental,
pubmed-meshheading:18481824-Male,
pubmed-meshheading:18481824-Random Allocation,
pubmed-meshheading:18481824-Rats,
pubmed-meshheading:18481824-Rats, Inbred F344,
pubmed-meshheading:18481824-Stem Cell Transplantation,
pubmed-meshheading:18481824-Stem Cells,
pubmed-meshheading:18481824-Transfection,
pubmed-meshheading:18481824-Urokinase-Type Plasminogen Activator
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pubmed:year |
2008
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pubmed:articleTitle |
Transplantation of urokinase-type plasminogen activator gene-modified bone marrow-derived liver stem cells reduces liver fibrosis in rats.
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pubmed:affiliation |
Department of Gastroenterology, Xinhua Hospital, College of Medicine, Shanghai Jiao Tong University, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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