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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-5-26
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pubmed:abstractText |
A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2). The preliminary biological test showed that most of the compounds displayed a high inhibitory activity against MMP-2 and a low activity against APN except compound B6 which exhibited good potency (IC(50)=13.2microM) similar with APN inhibitor Bestatin (IC(50)=15.5microM), and could be used as lead compound in the future.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5473-81
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pubmed:meshHeading |
pubmed-meshheading:18467109-Antigens, CD13,
pubmed-meshheading:18467109-Crystallography, X-Ray,
pubmed-meshheading:18467109-Drug Design,
pubmed-meshheading:18467109-Drug Evaluation, Preclinical,
pubmed-meshheading:18467109-Inhibitory Concentration 50,
pubmed-meshheading:18467109-Leucine,
pubmed-meshheading:18467109-Lysine,
pubmed-meshheading:18467109-Matrix Metalloproteinase 2,
pubmed-meshheading:18467109-Models, Molecular,
pubmed-meshheading:18467109-Molecular Structure,
pubmed-meshheading:18467109-Quantitative Structure-Activity Relationship,
pubmed-meshheading:18467109-Stereoisomerism,
pubmed-meshheading:18467109-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors.
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pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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