rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-7-8
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pubmed:abstractText |
Human hepatocellular carcinoma (HCC) can invade the portal vein and metastasize to other parts of the liver. Currently, the molecular and cellular mechanisms underlying intrahepatic metastasis of HCC are poorly understood. Tumor invasiveness could be considered an aspect of dysregulated motility, and the mechanisms that inhibit cell movement are considered to counteract the spreading of cancer cells through the liver. Accumulating observations suggest that the CD81 tetraspanin may have an inhibitory effect on cell movement.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Phosphatidylinositol 4-Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ACTN4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Actinin,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD81,
http://linkedlifedata.com/resource/pubmed/chemical/CD81 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0012
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-256.e1
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18466772-1-Phosphatidylinositol 4-Kinase,
pubmed-meshheading:18466772-Actin Cytoskeleton,
pubmed-meshheading:18466772-Actinin,
pubmed-meshheading:18466772-Animals,
pubmed-meshheading:18466772-Antigens, CD,
pubmed-meshheading:18466772-Antigens, CD81,
pubmed-meshheading:18466772-Carcinoma, Hepatocellular,
pubmed-meshheading:18466772-Cell Line, Tumor,
pubmed-meshheading:18466772-Cell Movement,
pubmed-meshheading:18466772-Colorectal Neoplasms,
pubmed-meshheading:18466772-Green Fluorescent Proteins,
pubmed-meshheading:18466772-Humans,
pubmed-meshheading:18466772-Liver Neoplasms,
pubmed-meshheading:18466772-Neoplasm Transplantation,
pubmed-meshheading:18466772-Rats,
pubmed-meshheading:18466772-Rats, Nude,
pubmed-meshheading:18466772-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma.
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pubmed:affiliation |
Department of Internal Medicine, Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy. antonio.mazzocca@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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