Source:http://linkedlifedata.com/resource/pubmed/id/18455002
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-5-5
|
| pubmed:abstractText |
Chronic allograft nephropathy (CAN) is the most frequent cause of chronic dysfunction and late loss of renal allografts. Epithelial mesenchymal transition (EMT) has been identified as responsible for the presence of activated interstitial fibroblasts (myofibroblasts) and transforming growth factor beta (TGF-beta)/Smad is the key signaling mediator. It has been proposed that the bone morphogenetic protein 7 (BMP-7) antagonist, Gremlin, could participate in EMT, as a downstream mediator of TGF-beta.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0041-1345
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
734-9
|
| pubmed:meshHeading |
pubmed-meshheading:18455002-Cell Differentiation,
pubmed-meshheading:18455002-Chronic Disease,
pubmed-meshheading:18455002-Epithelial Cells,
pubmed-meshheading:18455002-Fibrosis,
pubmed-meshheading:18455002-Humans,
pubmed-meshheading:18455002-In Situ Hybridization,
pubmed-meshheading:18455002-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18455002-Kidney Transplantation,
pubmed-meshheading:18455002-Mesoderm,
pubmed-meshheading:18455002-Postoperative Complications,
pubmed-meshheading:18455002-Transplantation, Homologous
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy.
|
| pubmed:affiliation |
Division of Nephrology, School of Medicine, Universidad Austral, Valdivia, Chile.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|