Linked Life Data

1845141

Source:http://linkedlifedata.com/resource/pubmed/id/1845141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-7-1
pubmed:abstractText
These studies have clarified a number of issues regarding the genetic control of extragonadal aromatase expression in birds carrying the henny-feathering trait. The marked increased in extragonadal aromatase expression of a unique species of aromatase mRNA is apparently controlled by a retrovirus. We have not yet established whether this promoter is the consequence of a new retroviral insertion or is due to a mutation in a preexisting retrovirus. It is of interest in this regard that the chicken aromatase gene is located in a region of chromosome 1 known to be rich in retroviral insertions. Second, the relationship of the henny-feathering trait to normal and abnormal extragonadal aromatase expression in man remains to be determined. At one extreme, it is possible that a similar mechanism may underlie syndromes typified by increases in extraglandular aromatase expression. Even if the parallel proves to be less exact, the Sebright chicken provides important insight into how aromatase expression may be modulated differently in different tissues. Finally, the discovery that retroviral sequences appear to modulate the expression of aromatase in extragonadal tissues represents an unusual method by which the genetic control of genes can be altered. In the case of the henny-feathering trait, the alteration in the dimorphic feathering pattern was the principal clue to the altered regulation of extragonadal aromatase. This relation is in keeping with the other examples of altered gene expression caused by retroviruses that have also caused morphologic alterations such as changes in coat color or the appearance of neoplasms (for examples, see Refs. 14-16).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0066-9458
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Aromatase expression in extragonadal tissues of the Sebright chicken is controlled by a retroviral promoter.
pubmed:affiliation
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8857.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't