rdf:type |
|
lifeskim:mentions |
umls-concept:C0022567,
umls-concept:C0086418,
umls-concept:C0851285,
umls-concept:C1150553,
umls-concept:C1257757,
umls-concept:C1325180,
umls-concept:C1325181,
umls-concept:C1414371,
umls-concept:C1418898,
umls-concept:C1519755,
umls-concept:C1522449,
umls-concept:C1565860,
umls-concept:C1705323
|
pubmed:issue |
12
|
pubmed:dateCreated |
2008-11-25
|
pubmed:abstractText |
Considerable evidence has demonstrated that UVB irradiation is a strong carcinogen for nonmelanoma skin cancer. Up-regulation of cyclooxygenase-2 (Cox-2) has been shown to be a crucial event in human keratinocytes in their responses to UVB irradiation. To further understand the molecular mechanisms governing Cox-2 regulation, we found that UVB irradiation significantly increased Cox-2 mRNA stability by inducing cytoplasmic localization and protein abundance of human antigen R (HuR). We also found that AMP-activated kinase (AMPK) mediates these events and that UVB reduces AMPK activity by down-regulating LKB1 kinase. Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1098-2744
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
974-83
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:18449856-AMP-Activated Protein Kinases,
pubmed-meshheading:18449856-Antigens, Surface,
pubmed-meshheading:18449856-Cell Line, Transformed,
pubmed-meshheading:18449856-Cyclooxygenase 2,
pubmed-meshheading:18449856-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:18449856-Humans,
pubmed-meshheading:18449856-Keratinocytes,
pubmed-meshheading:18449856-RNA Stability,
pubmed-meshheading:18449856-RNA-Binding Proteins,
pubmed-meshheading:18449856-Transfection,
pubmed-meshheading:18449856-Ultraviolet Rays
|
pubmed:year |
2008
|
pubmed:articleTitle |
UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes.
|
pubmed:affiliation |
Arizona Cancer Center, Tucson, Arizona 85724, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|