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pubmed-article:18448481pubmed:abstractTextBasic calcium phosphate (BCP) crystals have been implicated in the pathogenesis of OA and stimulate cyclo-oxygenase (COX) expression and PGE(2) production. This study aimed to elucidate the mechanism of COX-1 up-regulation by BCP crystals and to characterize the PGs produced in OA synovial fibroblasts (OASFs) in response to BCP crystals.lld:pubmed
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pubmed-article:18448481pubmed:articleTitleMechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts.lld:pubmed
pubmed-article:18448481pubmed:affiliationDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons of Ireland. eamonn.molloy@ireland.comlld:pubmed
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pubmed-article:18448481pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed