rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-6-18
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pubmed:abstractText |
Basic calcium phosphate (BCP) crystals have been implicated in the pathogenesis of OA and stimulate cyclo-oxygenase (COX) expression and PGE(2) production. This study aimed to elucidate the mechanism of COX-1 up-regulation by BCP crystals and to characterize the PGs produced in OA synovial fibroblasts (OASFs) in response to BCP crystals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Epoprostenol,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/calcium phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1462-0332
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
965-71
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pubmed:meshHeading |
pubmed-meshheading:18448481-Calcium Phosphates,
pubmed-meshheading:18448481-Cells, Cultured,
pubmed-meshheading:18448481-Crystallization,
pubmed-meshheading:18448481-Cyclooxygenase 1,
pubmed-meshheading:18448481-Cyclooxygenase 2,
pubmed-meshheading:18448481-Dinoprostone,
pubmed-meshheading:18448481-Epoprostenol,
pubmed-meshheading:18448481-Fibroblasts,
pubmed-meshheading:18448481-Humans,
pubmed-meshheading:18448481-Interleukin-1beta,
pubmed-meshheading:18448481-Osteoarthritis,
pubmed-meshheading:18448481-RNA, Messenger,
pubmed-meshheading:18448481-Signal Transduction,
pubmed-meshheading:18448481-Synovial Membrane,
pubmed-meshheading:18448481-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
Mechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts.
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pubmed:affiliation |
Department of Molecular and Cellular Therapeutics, Royal College of Surgeons of Ireland. eamonn.molloy@ireland.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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