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pubmed-article:1844684pubmed:abstractTextWhether a one-sided or a two-sided p value should be used for reporting the results of an analysis should be determined by the a priori question the investigation seeks to answer. It is concluded that one-sided p values are appropriate in clinical trials whose objective is to provide definitive, confirmatory evidence of efficacy of pharmaceutical compounds.lld:pubmed
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pubmed-article:1844684pubmed:articleTitleOne-sided or two-sided p values: which most appropriately address the question of drug efficacy?lld:pubmed
pubmed-article:1844684pubmed:affiliationBiopharmaceutical Research Consultants, Inc., Ann Arbor, Michigan 48105.lld:pubmed
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