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rdf:type |
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lifeskim:mentions |
umls-concept:C0004153,
umls-concept:C0006675,
umls-concept:C0063695,
umls-concept:C0175630,
umls-concept:C0205042,
umls-concept:C0441889,
umls-concept:C1334074,
umls-concept:C1421435,
umls-concept:C1749467,
umls-concept:C1882417,
umls-concept:C2603343
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pubmed:issue |
2
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pubmed:dateCreated |
2008-12-1
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pubmed:abstractText |
Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-95159,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-95165,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-95169,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL071251-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL071251-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL071251-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL071251-05,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL071051,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL071205,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL071250,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL071252,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL071259
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-10699175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-10733371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-11212883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-11254454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-11583751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-12397006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-12866607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-14574645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-14685227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-14704198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-15078854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-15297300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-15502096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-15618373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-15736117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-15983262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-16432463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-16625213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-16733712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-16916657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-16938546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-16978373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-7561056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-9416885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18420209-9439492
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-44
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18420209-Aged,
pubmed-meshheading:18420209-Aged, 80 and over,
pubmed-meshheading:18420209-Alleles,
pubmed-meshheading:18420209-Atherosclerosis,
pubmed-meshheading:18420209-Calcium,
pubmed-meshheading:18420209-Coronary Vessels,
pubmed-meshheading:18420209-Female,
pubmed-meshheading:18420209-Haplotypes,
pubmed-meshheading:18420209-Humans,
pubmed-meshheading:18420209-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18420209-Male,
pubmed-meshheading:18420209-Middle Aged,
pubmed-meshheading:18420209-Polymorphism, Genetic,
pubmed-meshheading:18420209-Polymorphism, Single Nucleotide,
pubmed-meshheading:18420209-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2008
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pubmed:articleTitle |
ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA).
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pubmed:affiliation |
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA. suzetteb@umn.edu
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pubmed:publicationType |
Journal Article,
Multicenter Study,
Research Support, N.I.H., Extramural
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