| pubmed-article:18406458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C0021102 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C1704229 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C1705604 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C0079949 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C1697272 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C1522408 | lld:lifeskim |
| pubmed-article:18406458 | lifeskim:mentions | umls-concept:C1704806 | lld:lifeskim |
| pubmed-article:18406458 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:18406458 | pubmed:dateCreated | 2008-4-28 | lld:pubmed |
| pubmed-article:18406458 | pubmed:abstractText | Implant osseointegration, defined as bone apposition and functional fixation, is a requisite for clinical success in orthopaedic and dental applications, many of which are restricted by implant loosening. Modification of implants to present bioactive motifs such as the RGD cell-adhesive sequence from fibronectin (FN) represents a promising approach in regenerative medicine. However, these biomimetic strategies have yielded only marginal enhancements in tissue healing in vivo. In this study, clinical-grade titanium implants were grafted with a non-fouling oligo(ethylene glycol)-substituted polymer coating functionalized with controlled densities of ligands of varying specificity for target integrin receptors. Biomaterials presenting the alpha5beta1-integrin-specific FN fragment FNIII 7-10 enhanced osteoblastic differentiation in bone marrow stromal cells compared to unmodified titanium and RGD-presenting surfaces. Importantly, FNIII 7-10-functionalized titanium significantly improved functional implant osseointegration compared to RGD-functionalized and unmodified titanium in vivo. This study demonstrates that bioactive coatings that promote integrin binding specificity regulate marrow-derived progenitor osteoblastic differentiation and enhance healing responses and functional integration of biomedical implants. This work identifies an innovative strategy for the rational design of biomaterials for regenerative medicine. | lld:pubmed |
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| pubmed-article:18406458 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18406458 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18406458 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18406458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18406458 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18406458 | pubmed:issn | 0142-9612 | lld:pubmed |
| pubmed-article:18406458 | pubmed:author | pubmed-author:GarcíaAndrés... | lld:pubmed |
| pubmed-article:18406458 | pubmed:author | pubmed-author:CollardDavid... | lld:pubmed |
| pubmed-article:18406458 | pubmed:author | pubmed-author:ReyesCatherin... | lld:pubmed |
| pubmed-article:18406458 | pubmed:author | pubmed-author:BurnsKellie... | lld:pubmed |
| pubmed-article:18406458 | pubmed:author | pubmed-author:PetrieTimothy... | lld:pubmed |
| pubmed-article:18406458 | pubmed:author | pubmed-author:RaynorJenny... | lld:pubmed |
| pubmed-article:18406458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18406458 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:18406458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18406458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18406458 | pubmed:pagination | 2849-57 | lld:pubmed |
| pubmed-article:18406458 | pubmed:dateRevised | 2011-4-1 | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:meshHeading | pubmed-meshheading:18406458... | lld:pubmed |
| pubmed-article:18406458 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18406458 | pubmed:articleTitle | The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration. | lld:pubmed |
| pubmed-article:18406458 | pubmed:affiliation | Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States. | lld:pubmed |
| pubmed-article:18406458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18406458 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18406458 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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