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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2008-4-28
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pubmed:abstractText |
Implant osseointegration, defined as bone apposition and functional fixation, is a requisite for clinical success in orthopaedic and dental applications, many of which are restricted by implant loosening. Modification of implants to present bioactive motifs such as the RGD cell-adhesive sequence from fibronectin (FN) represents a promising approach in regenerative medicine. However, these biomimetic strategies have yielded only marginal enhancements in tissue healing in vivo. In this study, clinical-grade titanium implants were grafted with a non-fouling oligo(ethylene glycol)-substituted polymer coating functionalized with controlled densities of ligands of varying specificity for target integrin receptors. Biomaterials presenting the alpha5beta1-integrin-specific FN fragment FNIII 7-10 enhanced osteoblastic differentiation in bone marrow stromal cells compared to unmodified titanium and RGD-presenting surfaces. Importantly, FNIII 7-10-functionalized titanium significantly improved functional implant osseointegration compared to RGD-functionalized and unmodified titanium in vivo. This study demonstrates that bioactive coatings that promote integrin binding specificity regulate marrow-derived progenitor osteoblastic differentiation and enhance healing responses and functional integration of biomedical implants. This work identifies an innovative strategy for the rational design of biomaterials for regenerative medicine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-10486010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-10525792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-10547359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-10723092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-10828842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-11204428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-11310352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-11585340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-12010163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-12297042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-12700132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-14561098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15057821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15229544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15275815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15542130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15621242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15637621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-15827122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-16000373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-16002137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-16618502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-16846640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-16960836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-17298493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-17448533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-17457829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-8968516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-9151803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18406458-9182762
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0142-9612
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2849-57
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pubmed:dateRevised |
2011-4-1
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration.
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pubmed:affiliation |
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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