Linked Life Data

18396212

Source:http://linkedlifedata.com/resource/pubmed/id/18396212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-4-8
pubmed:abstractText
Abnormal expression of the costimulatory molecules cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28, and inducible co-stimulator (ICOS) leads to disturbances of immune response and an increased risk of cancer. An extended study was undertaken to evaluate the association among the polymorphisms CTLA-4c.49A>G, CTLA-4g.319C>T, CTLA-4g.*642AT(8_33), CD28c.17+3T>C, and ICOSc.1554+4GT(8_15) and susceptibility to B-cell chronic lymphocytic leukemia (B-CLL) in the Polish population. The study revealed increased frequency of the CTLA-4g.319C>T [T] allele and the CTLA-4g.319C>T [T] phenotype in B-CLL patients compared with healthy controls (p = 0.003, odds ratio [OR] = 1.73; and p = 0.009, OR = 1.74, respectively). The presence of the CD28c.17+3T>C [C] allele and the CD28c.17+3T>C [C] phenotype increased the OR of B-CLL to 1.59 (p = 0.007) and 1.74 (p = 0.007), respectively. Either CTLA-4g.319C>T or CD28c.17+3T>C was associated with time to Rai stage progression. The distributions of the alleles and genotypes of the ICOS gene significantly differed between patients and controls (p = 0.0009 and p = 0.006, respectively). Individuals possessing short alleles were 2.02 times more prone to B-CLL than others (p = 0.001), whereas carriers of long alleles were protected from B-CLL (p = 0.02, OR = 0.62). The haplotype association study and multivariate analysis confirmed the association of CTLA-4g.319C>T and ICOSc.1554+4GT(8_15) gene polymorphisms with B-CLL. The polymorphic sites CTLA-4c.49A>G and CTLA-4g.*642AT(8_33) did not correlate with B-CLL. Our results are the first in the literature to report that gene polymorphism of the costimulatory molecules CTLA-4, CD28, and ICOS contributes to susceptibility to B-CLL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-201
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:18396212-Aged, pubmed-meshheading:18396212-Alleles, pubmed-meshheading:18396212-Antigens, CD, pubmed-meshheading:18396212-Antigens, CD28, pubmed-meshheading:18396212-Antigens, Differentiation, pubmed-meshheading:18396212-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:18396212-CTLA-4 Antigen, pubmed-meshheading:18396212-Female, pubmed-meshheading:18396212-Gene Frequency, pubmed-meshheading:18396212-Genetic Predisposition to Disease, pubmed-meshheading:18396212-Genotype, pubmed-meshheading:18396212-Haplotypes, pubmed-meshheading:18396212-Humans, pubmed-meshheading:18396212-Inducible T-Cell Co-Stimulator Protein, pubmed-meshheading:18396212-Leukemia, Lymphocytic, Chronic, B-Cell, pubmed-meshheading:18396212-Linkage Disequilibrium, pubmed-meshheading:18396212-Male, pubmed-meshheading:18396212-Middle Aged, pubmed-meshheading:18396212-Multivariate Analysis, pubmed-meshheading:18396212-Phenotype, pubmed-meshheading:18396212-Poland, pubmed-meshheading:18396212-Polymorphism, Genetic
pubmed:year
2008
pubmed:articleTitle
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population.
pubmed:affiliation
Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't