|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003402,
umls-concept:C0007634,
umls-concept:C0011164,
umls-concept:C0030685,
umls-concept:C0030705,
umls-concept:C0040573,
umls-concept:C0205263,
umls-concept:C0339573,
umls-concept:C0391871,
umls-concept:C0521451,
umls-concept:C0680255,
umls-concept:C0812281,
umls-concept:C1283071,
umls-concept:C1457869,
umls-concept:C1545588,
umls-concept:C1963578,
umls-concept:C2245017
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2008-4-3
|
|
pubmed:abstractText |
There is growing evidence that oxidative stress contributes to the progression of primary open-angle glaucoma (POAG), a leading cause of irreversible blindness worldwide. The authors provide evidence that mitochondrial dysfunction is a possible mechanism for the loss of trabecular meshwork (TM) cells in persons with POAG.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex I,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Rotenone,
http://linkedlifedata.com/resource/pubmed/chemical/Uncoupling Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial permeability...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0146-0404
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1447-58
|
|
pubmed:meshHeading |
pubmed-meshheading:18385062-Acetylcysteine,
pubmed-meshheading:18385062-Adenosine Triphosphate,
pubmed-meshheading:18385062-Adolescent,
pubmed-meshheading:18385062-Adult,
pubmed-meshheading:18385062-Annexin A5,
pubmed-meshheading:18385062-Antioxidants,
pubmed-meshheading:18385062-Apoptosis,
pubmed-meshheading:18385062-Cells, Cultured,
pubmed-meshheading:18385062-Cyclosporine,
pubmed-meshheading:18385062-Cytochromes c,
pubmed-meshheading:18385062-Electron Transport Complex I,
pubmed-meshheading:18385062-Glaucoma, Open-Angle,
pubmed-meshheading:18385062-Humans,
pubmed-meshheading:18385062-L-Lactate Dehydrogenase,
pubmed-meshheading:18385062-Membrane Potential, Mitochondrial,
pubmed-meshheading:18385062-Middle Aged,
pubmed-meshheading:18385062-Mitochondrial Membrane Transport Proteins,
pubmed-meshheading:18385062-Oxidative Stress,
pubmed-meshheading:18385062-Reactive Oxygen Species,
pubmed-meshheading:18385062-Rotenone,
pubmed-meshheading:18385062-Trabecular Meshwork,
pubmed-meshheading:18385062-Uncoupling Agents,
pubmed-meshheading:18385062-Vitamin E
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
|
|
pubmed:affiliation |
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
