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rdf:type |
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lifeskim:mentions |
umls-concept:C0022646,
umls-concept:C0030190,
umls-concept:C0086222,
umls-concept:C0086418,
umls-concept:C0205107,
umls-concept:C0205296,
umls-concept:C0242184,
umls-concept:C0333348,
umls-concept:C0348080,
umls-concept:C0552639,
umls-concept:C1551336,
umls-concept:C1705733,
umls-concept:C2917405
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pubmed:issue |
8
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pubmed:dateCreated |
2008-7-29
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pubmed:abstractText |
Hypoxia and inflammation, an unavoidable milieu for renal tubular cells during the development of renal fibrosis, reportedly up-regulate production of plasminogen activator inhibitor-1 (PAI-1), a promoter of tissue fibrosis. Peroxisome proliferator-activated receptor (PPAR)-gamma agonists may modulate renal fibrosis progression via their anti-inflammatory effects in a PPAR-gamma-dependent or -independent manner. However, no information is known about the effects of PPAR-gamma agonists on PAI-1 expression in human proximal renal tubular cells (HPTECs) under hypoxia and/or inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-deoxy-delta(12,14)-prostaglandin...,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/SERPINE1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/pioglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1460-2385
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2496-503
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18367541-Cell Hypoxia,
pubmed-meshheading:18367541-Cells, Cultured,
pubmed-meshheading:18367541-Flavonoids,
pubmed-meshheading:18367541-Genistein,
pubmed-meshheading:18367541-Humans,
pubmed-meshheading:18367541-Inflammation,
pubmed-meshheading:18367541-Kidney Tubules, Proximal,
pubmed-meshheading:18367541-MAP Kinase Kinase 1,
pubmed-meshheading:18367541-PPAR gamma,
pubmed-meshheading:18367541-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:18367541-Prostaglandin D2,
pubmed-meshheading:18367541-Protein Kinase Inhibitors,
pubmed-meshheading:18367541-Protein-Tyrosine Kinases,
pubmed-meshheading:18367541-Thiazolidinediones,
pubmed-meshheading:18367541-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions.
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pubmed:affiliation |
Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida, Fukui 910-1193, Japan. hkimura@u-fukui.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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