GENERIC 18360305

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0014257, umls-concept:C0017504, umls-concept:C0086418, umls-concept:C0162371, umls-concept:C0205431, umls-concept:C1257975, umls-concept:C1947989
pubmed:issue	1
pubmed:dateCreated	2008-6-26
pubmed:abstractText	Endothelial progenitor cells (EPCs) are used for angiogenic therapies and as biomarkers of cardiovascular disease. Human umbilical cord blood (UCB) is a rich source of endothelial colony forming cells (ECFCs), which are EPCs with robust proliferative potential that may be useful for clinical vascular regeneration. Previous studies show that hematopoietic progenitor cells are increased in premature UCB compared with term controls. Based on this paradigm, we hypothesized that premature UCB would be an enriched source of ECFCs. Thirty-nine UCB samples were obtained from premature infants (24-37 wk gestational age (GA)) and term controls. ECFC colonies were enumerated, clonally isolated, and identified by expression of endothelial cell surface antigens and functional analysis. GA of 33-36 wk UCB yielded predominantly ECFC colonies at equivalent numbers to term infants. UCB from 24 to 28 wk GA infants had significantly fewer ECFCs. Surprisingly, 24-28 wk GA UCB yielded predominantly mesenchymal stem cell (MSC) colonies, capable of differentiating into adipocytes, chondrocytes, and osteocytes. MSCs were rarely identified in 37-40 wk GA UCB. These studies demonstrate that circulating MSCs and ECFCs appear at different GA in the human UCB, and that 24-28 wk GA UCB may be a novel source of MSCs for therapeutic use in human diseases.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P01 HL053586-11A1, http://linkedlifedata.com/resource/pubmed/grant/P50 NS052606-03, http://linkedlifedata.com/resource/pubmed/grant/R21 HL088885-01
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0100714
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0031-3998
pubmed:author	pubmed-author:BesslerWaylan KWK, pubmed-author:CaseJamieJ, pubmed-author:FosterDavidD, pubmed-author:GoebelW ScottWS, pubmed-author:HanelineLaura SLS, pubmed-author:IngramDavid ADA, pubmed-author:JavedM JawadMJ, pubmed-author:MeadLaura ELE, pubmed-author:PraterDanielD, pubmed-author:YoderMervin CMC
pubmed:issnType	Print
pubmed:volume	64
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	68-73
pubmed:dateRevised	2010-4-29
pubmed:meshHeading	pubmed-meshheading:18360305-Adipocytes, pubmed-meshheading:18360305-Antigens, CD, pubmed-meshheading:18360305-Cell Differentiation, pubmed-meshheading:18360305-Cell Proliferation, pubmed-meshheading:18360305-Cell Shape, pubmed-meshheading:18360305-Cells, Cultured, pubmed-meshheading:18360305-Chondrocytes, pubmed-meshheading:18360305-Endothelial Cells, pubmed-meshheading:18360305-Fetal Blood, pubmed-meshheading:18360305-Fetal Stem Cells, pubmed-meshheading:18360305-Gestational Age, pubmed-meshheading:18360305-Humans, pubmed-meshheading:18360305-Infant, Newborn, pubmed-meshheading:18360305-Infant, Premature, pubmed-meshheading:18360305-Mesenchymal Stem Cells, pubmed-meshheading:18360305-Neovascularization, Physiologic, pubmed-meshheading:18360305-Osteocytes, pubmed-meshheading:18360305-Phenotype
pubmed:year	2008
pubmed:articleTitle	Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood.
pubmed:affiliation	Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, N.I.H., Extramural